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Evolution of the HDL hypothesis: Current insights

Listen to Prof Stephen Nicholls provide his expert insights on why the HDL hypothesis is shifting from a focus on HDL levels to HDL function. He describes ApoA-I, the key functional component of HDL, and the role it plays in the mechanism of cholesterol efflux, the pivotal first step in reverse cholesterol transport

Prof Stephen Nicholls

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ACC 2024 Industry-Expert Theater
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The HDL Hypothesis: Past, Present, and Future

Following an AMI, the risk of recurrent CV events remains high, particularly during the first 90 days. Despite advances in standard of care treatment, an unmet therapeutic need persists for these patients. This engaging symposium brings together an expert faculty to explore the mechanism of cholesterol efflux and its impact on post-AMI CV events. The panel will outline the pivotal role ApoA-I, a key functional component of HDL, plays in this setting, and discuss recent developments in the high-risk post-AMI landscape.

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Susan Gabriel, Ph.D.
ESC22

Recurrent CV events post-AMI in patients with MVD: A retrospective study in the UK

Listen to Dr. Susan Gabriel share her insights on risk factors for recurrent cardiovascular events following myocardial infarction in a large real-world data analysis of 78,000 patients with multivessel disease.

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Abbreviations

ACC, American College of Cardiology; ACS, acute coronary syndrome; AHA, American Heart Association; AMI, acute myocardial infarction; ApoA-I, apolipoprotein A-I; ASCVD, atherosclerotic cardiovascular disease; CV, cardiovascular; ESC, European Society of Cardiology; HDL, high-density lipoprotein; LDL, low-density lipoprotein 

 

USA-GEN-0051 | March 2024